Technology

NBI

Extracellular vesicles (EVs) are membranous particles, abundantly released by the cells in the extracellular space and in the biological fluids. EVs contain nucleic acids, proteins and lipids and their molecular content mirrors the one of the cell of origin. They are therefore a valuable source of information and a faithful representation of the state of health of the releasing cells. EVBiome is leveraging on AEVA Biotech’s proprietary EVs isolation technology to capture EVs from biological fluids in a rapid, reproducible, cost-effective and high-throughput way. The innovative method is called NBI (Nickel Based Isolation) and exploits beads functionalized with nickel cations to recover intact EVs, still carrying their original features and thus usable for molecular characterizations of their biological content.

BLOOD MICRODISSECTION

At the forefront of biomarker discovery, we specialize in the analysis of circulating extracellular vesicles to unlock clinically actionable insights. Drawing inspiration from tissue microdissection in cancer tissue biomarkers, we have developed a know-how enabling a unique form of plasma or serum microdissection — a process that fractionates blood samples into distinct components prior to analysis. By doing so, we move beyond conventional bulk plasma screening and dramatically enhance the sensitivity and specificity of biomarker detection. This refined approach routinely reveals biomarker signals that would otherwise remain undetectable in whole plasma or serum.